Norman Sproch

Analytical Chemistry

nsproch@gmail.com


The PDI-PIXE-MS System

vandegraaff schematic vandegraaff accelerator
pdipixems xraylonsource

Papers; Publications; Presentations; Patents


  1. Sproch, N. Fernando, Q., The Development of Particle Desorption Ionization Particle-Induced X-Ray Emission Mass Spectrometry, PDI-PIXE-MS, in preparation.
  2. Sproch, N., Fernando, Q., Accelerator-Based Heavy Ion Particle Desorption Ionization Using a Quadrupole Mass Spectrometer”, in preparation.
  3. Sproch, N., Fernando, Q., A Method for the Decontamination of Mercury Contaminated Mine Tailings Based on Particle Induced X-Ray Emission Spectroscopy, in preparation.
  4. Sproch, N., PDI-PIXE-MS: Particle Desorption Ionization Particle-Induced X-Ray Emission Mass Spectrometry, Ph.D. Dissertation, 2007. Dissertation (PDF 137 MB)
  5. Sproch, N. Method for Characterization of 3-Dimensional Conformation of Proteins and Protein Complexes Employing Mass Spectrometric Analysis and Computational Feedback Modeling, Patent #7,047,171, Issued May 16, 2006, United States Patent and Trademark Office, Washington, D.C. Patent (PDF 1.7 MB)
  6. Antolak, A.J., Morse, D.H., Grant, P.G., Sproch, N., Fernando, Q., "Spatially Resolved, Microscopic Surface Chemistry Using Megavolt Energy Focused Ion Beams", Applications of Accelerators in Research and Industry: 17th International Conference, ed. Duggan, J.L., Morgan, I.L., AIP, CP680, 359-363, 2003.
  7. D. H. Morse, P. G. Grant, A. J. Antolak, N. Sproch, Q. Fernando, Accelerator-Based Surface Chemistry by Combined Time-of-Flight Mass Spectrometry (TOF-MS) and Particle-Induced X-ray Emission (PIXE), Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, June 2-6, 2002, Orlando FL.
  8. Sproch, N., Ashbaugh, M.D., Morse, D., Grant, P., McIntyre Jr., L.C., Antolak, A., Fernando, Q., "PD/PIXE/MS: Particle Desorption Particle Induced X-ray Emission Mass Spectrometry", Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics; May 27-31, 2001, Chicago, IL.
    • Note: Reference #8 is the first presentation of experimental results demonstrating the collection of elemental X-ray data simultaneously with the collection of ions for mass analysis using a multiplexed instrument and X-ray/Ion source.
  9. Sproch, N., Molecular Mechanics Interpretation of Polypeptide Fragmentation from Dissociative Mass Spectrometry, Slide Presentation, 1997. Slide Show (2.5 MB)
  10. Sproch, N. and Kruger, T. L. "Electrospray Ionization Source and Method for Mass Spectrometric Analysis", Patent #5,504,327, Issued April 2, 1996, United States Patent and Trademark Office, Washington, D.C. Patent (PDF 1.6 MB)
  11. Squires, R. R., Sunderlin, L. S., Chyall, L. J., Hill, B. T., Hu, J., Poutsma, J. C., Seburg, R. A., Byrd, D., Sproch, N. Flowing Afterspray. Combining Electrospray Ionization with the Flowing Afterglow Technique The 44th ASMS Conference on Mass Spectrometry and Allied Topics, Portland, OR, 1996, 1010.
  12. Sproch, N., Begin, K. J., Morris, R. J. "An Introductory Undergraduate LC/Particle Beam/MS Experiment" J. Chem. Ed., 1996, 73, A33-A39.
  13. Sproch, N., Electrospray Mass Spectrometry: An Investigation of Non-Covalent Interactions of Cytochrome c/ Crown Ether Complexes and Applied Methods of Computational Chemistry, M.S. Thesis, 1994. Thesis (PDF 3.5 MB)
    • Note: Reference #13 is the first report of combined experimental/computational results using electrospray mass spectrometry of crown ethers non-covalently binding to protein amino acid residues.
  14. Sproch, N. and Kruger, T. L. "Analytical Applications of Protein/Crown Ether Complexes in Electrospray Mass Spectrometry" Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy, Abstracts, Chicago, IL, Feb. 27-Mar. 4, 1994, 464P.
  15. Sproch, N. and Kruger, T. L. "Construction and Characterization of a Small-Bore Electrospray Ionization Source" J. Am. Soc. Mass Spectrom. 1993, 4, 964-967.
  16. Sproch, N. and Kruger, T. L. "Non-Covalent Interactions of Crown Ethers With Cytochrome c Using Electrospray Mass Spectrometry" The 41st ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, CA, 1993, 904a-904b.
    • Note: Reference #16 is the first presentation of experimental results demonstrating the molecular recognition of protonated basic amino acid residues on a protein using crown ethers as probe molecules, via electrospray mass spectrometry.
  17. Sproch, N. and Kruger, T. L. "Methods of Computational Chemistry Applied to Electrospray Mass Spectrometry" 109th Indiana Academy of Science Programs and Abstracts, Purdue University, W. Lafayette, IN, Nov. 4-5, 1993, p31.
  18. Morris, R. J., Begin, K. J., Sproch, N. "An Introductory LC/Particle Beam/MS Experiment" 109 th Indiana Academy of Science Programs and Abstracts, Purdue University, W. Lafayette, IN, Nov. 4-5, 1993, p34.
  19. Sproch, N. and Kruger, T. L. "Methods of Computational Chemistry Applied to Electrospray Mass Spectrometry" North Carolina ACS Symposium on Molecular Modeling: Integration of Theory and Experiment, Abstracts, Research Triangle Park, MCNC, NC, Oct. 21-23, 1993, p36.
  20. Morris, R. J., Begin, K. J., Sproch, N. "An Introductory LC/Particle Beam/MS Experiment" American Chemical Society Regional Meeting, Pittsburgh, PA, Oct., 1993.
  21. Morris, R. J., Begin, K. J., Sproch, N. "An Introductory LC/Particle Beam/MS Experiment" American Chemical Society National Meeting, Chicago, IL, Aug., 1993.
  22. Morris, R. J., Begin, K. J., Sproch, N. "An Introductory LC/Particle Beam/MS Experiment" American Chemical Society Great Lakes Regional Meeting, Marquette, MI, May, 1993.
  23. Sproch, N. and Kruger, T. L. "Development of an Electrospray Ionization Source for a Quadrupole Mass Spectrometer" 108th Indiana Academy of Science Programs and Abstracts, Ball State University, Muncie, IN, Nov. 5-6, 1992, p33.
  24. Sproch, N. "Computer-Aided Molecular Design Used In Developing Three Candidate Compounds", DowElanco, Proprietary Presentation, Greenfield, IN, Aug., 1990.
  25. Sproch, N. and Rybarczyk, J.P. "Sample Introduction Effects on the Excitation Mechanism in the Inductively Coupled Plasma" Proceedings of the Indiana Academy of Science, Indiana University-Purdue University at Ft. Wayne, Ft. Wayne, IN, 1983, 93, p143.